Ophthalmic Technology Assessment

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Descemet’s Stripping Endothelial Keratoplasty: Safety and Outcome OTA

A Report by the American Academy of Ophthalmology

Ophthalmic Technology Assessment Committee Cornea and Anterior Segment Disorders Panel: W. Barry Lee, MD; Deborah S. Jacobs, MD; David C. Musch, PhD, MPH; Stephen C. Kaufman, MD, PhD; William J. Reinhart, MD; Roni M. Shtein, MD

Published in Ophthalmology, September 2009, Vol. 116, 1818-1830
  • Evidence-based summary of safety and outcomes for DSEK/DSAEK
  • Most common complications:
    • Posterior graft dislocations
    • Endothelial graft rejection
    • Primary graft failure
    • Iatrogenic glaucoma
  • Average BCVA from 20/34 to 20/66 (mean, 9 months)
  • Evidence supports DSEK as a safe and effective treatment for corneal endothelial diseases
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